It was a dramatic win for Manchester United in the first leg of this game which the Reds were given a penalty after the final whistle of the game which was slotted in perfectly by Bruno Fernandes to give the Reds the 3 point. Let take a look at what you need to know before the game.
Anthony Martial may be out of the clash against Brighton after he picked up an injury on international duty, while Marcus Rashford pulled out of England senior team squad for international games, Mason Greenwood also pulled out of the U21 squad.
Paul Pogba is in line to make his first league appearance in two months.
Aaron Connolly has trained with Brighton after being substituted playing for the Republic of Ireland last week against Serbia. The 21-year-old could feature in the squad against Manchester United.
Adam Webster will miss out on the trip to Old Trafford as he continues his recovery from an ankle injury, with Tariq Lamptey and Solly March missing for the remainder of the season. Percy Tau is also quarantining after featuring for South Africa during the international break.
Manchester United have won the last five games against Brighton.
Form in the Premier League.
Manchester United have won three of their last five premier league game and draw the remaining two.
Brighton won two games out of their last five premier league game losing the rest.
Ole Gunner Solskjaer will want to keep the second position in the league and with the form they are our prediction is, Manchester United 3-0 Brighton.